Research Articles
Matrigel vs. Laminin for iPSC Culture: A Scientist's Guide to Selection, Optimization, and Xeno-Free Alternatives
This article provides a comprehensive comparison of Matrigel and laminin coatings for induced pluripotent stem cell (iPSC) culture, tailored for researchers and drug development professionals.
Sendai Virus Reprogramming: A Comprehensive Guide to Generating Integration-Free iPSCs for Research and Therapy
Sendai virus (SeV) vector technology has emerged as a leading method for generating induced pluripotent stem cells (iPSCs) without genomic integration, a critical safety consideration for clinical applications.
Revolutionizing ALS Research: iPSC-Derived Motor Neurons as Predictive Models for Drug Discovery
This article provides a comprehensive overview of the transformative role of induced pluripotent stem cell (iPSC)-derived motor neurons in modeling Amyotrophic Lateral Sclerosis (ALS).
iPSC-Derived Cardiomyocytes for Arrhythmia Studies: From Disease Modeling to Clinical Translation
Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have revolutionized cardiac arrhythmia research by providing a patient-specific platform for disease modeling, drug screening, and safety pharmacology.
Direct Reprogramming of Somatic Cells to iPSCs: A Comprehensive Guide to Protocols, Mechanisms, and Clinical Translation
This article provides a comprehensive and up-to-date analysis of the protocols for directly reprogramming somatic cells into induced pluripotent stem cells (iPSCs).
Feeder-Free Culture Systems for iPSC Maintenance: A Complete Guide for Researchers and Clinicians
Feeder-free culture systems have revolutionized induced pluripotent stem cell (iPSC) research by providing defined, xeno-free conditions that enhance experimental reproducibility and clinical applicability.
3D Cerebral Organoids from Pluripotent Stem Cells: Modeling Brain Development, Disease, and Drug Discovery
This article provides a comprehensive overview of 3D cerebral organoids derived from human pluripotent stem cells (hPSCs), a revolutionary technology that recapitulates key aspects of human brain development.
CRISPR-Cas9 and iPSCs: Revolutionizing Disease Modeling for Drug Discovery and Personalized Medicine
This article explores the powerful synergy between CRISPR-Cas9 gene editing and induced pluripotent stem cell (iPSC) technology, a combination that is revolutionizing disease modeling and therapeutic development.
Generating Kidney Organoids from iPSCs: A Comprehensive Guide for Disease Modeling and Drug Development
Kidney organoids derived from human induced pluripotent stem cells (iPSCs) have emerged as a transformative platform for modeling renal development and disease.
Differentiation of iPSCs into Insulin-Producing Beta Cells: A Comprehensive Guide for Research and Therapy Development
This article provides a comprehensive analysis of the process to differentiate human induced pluripotent stem cells (iPSCs) into functional, insulin-producing beta cells.