Research Articles
Integration-Free iPSC Generation: Strategies for Minimizing Transgenes in Clinical Applications
The generation of induced pluripotent stem cells (iPSCs) free of integrated transgenes is a critical step toward their safe clinical application in regenerative medicine and drug development.
Optimizing Neuronal Maturation from iPSCs: Strategies for Robust Models in Research and Drug Development
The efficient generation of mature, functional neurons from human induced pluripotent stem cells (iPSCs) is critical for advancing disease modeling and drug screening.
Strategies for Improving Reprogramming Efficiency: From Somatic Cells to Functional iPSCs
This article provides a comprehensive guide for researchers and drug development professionals on the latest strategies to enhance the efficiency and safety of induced pluripotent stem cell (iPSC) generation.
Safeguarding iPSC Integrity: Strategies to Prevent Genomic Instability in Long-Term Culture
This article provides a comprehensive guide for researchers and drug development professionals on managing genomic instability in induced pluripotent stem cells (iPSCs) during extended culture.
Strategies to Minimize Spontaneous Differentiation in iPSC Cultures: A Guide for Robust and Reproducible Research
Spontaneous differentiation remains a significant challenge in induced pluripotent stem cell (iPSC) culture, compromising experimental reproducibility and the efficacy of cell therapies.
Matrigel vs. Laminin for iPSC Culture: A Scientist's Guide to Selection, Optimization, and Xeno-Free Alternatives
This article provides a comprehensive comparison of Matrigel and laminin coatings for induced pluripotent stem cell (iPSC) culture, tailored for researchers and drug development professionals.
Sendai Virus Reprogramming: A Comprehensive Guide to Generating Integration-Free iPSCs for Research and Therapy
Sendai virus (SeV) vector technology has emerged as a leading method for generating induced pluripotent stem cells (iPSCs) without genomic integration, a critical safety consideration for clinical applications.
Revolutionizing ALS Research: iPSC-Derived Motor Neurons as Predictive Models for Drug Discovery
This article provides a comprehensive overview of the transformative role of induced pluripotent stem cell (iPSC)-derived motor neurons in modeling Amyotrophic Lateral Sclerosis (ALS).
iPSC-Derived Cardiomyocytes for Arrhythmia Studies: From Disease Modeling to Clinical Translation
Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have revolutionized cardiac arrhythmia research by providing a patient-specific platform for disease modeling, drug screening, and safety pharmacology.
Direct Reprogramming of Somatic Cells to iPSCs: A Comprehensive Guide to Protocols, Mechanisms, and Clinical Translation
This article provides a comprehensive and up-to-date analysis of the protocols for directly reprogramming somatic cells into induced pluripotent stem cells (iPSCs).