Research Articles
Modeling Alzheimer's Risk: Investigating APOE Isoform-Specific Effects in Human iPSC-Derived Neurons and Brain Cell Types
Human induced pluripotent stem cells (hiPSCs) have emerged as a transformative platform for investigating the mechanistic roles of Apolipoprotein E (APOE) isoforms in Alzheimer's Disease (AD) and other neurodegenerative conditions.
iPSC Disease Modeling for Rare Genetic Disorders: From Patient Cells to Precision Therapies
This article provides a comprehensive resource for researchers and drug development professionals on utilizing induced pluripotent stem cells (iPSCs) to model rare genetic diseases.
Modeling Tau Hyperphosphorylation in Human iPSC-Derived Neurons: From Mechanisms to Therapeutic Discovery
This article synthesizes current research on modeling tau hyperphosphorylation using human induced pluripotent stem cell (iPSC)-derived neurons, a system that recapitulates key aspects of Alzheimer's disease and related tauopathies.
hiPSC Models in Alzheimer's Disease: Bridging the Gap Between Familial and Sporadic Pathologies for Drug Discovery
This article provides a comprehensive analysis of human induced pluripotent stem cell (hiPSC) models for both familial (FAD) and sporadic (SAD) Alzheimer's disease.
Modeling Alzheimer's Disease Mechanisms with iPSCs: From Pathogenesis to Drug Discovery
This article provides a comprehensive analysis of how induced pluripotent stem cell (iPSC) models are revolutionizing Alzheimer's disease (AD) research.
Stem Cell Therapy Efficacy in Randomized Clinical Trials: A 2025 Landscape Analysis for Research and Development
This article provides a comprehensive analysis of the current efficacy and safety data from randomized clinical trials (RCTs) of stem cell therapies.
Biomaterial Scaffolds for Stem Cell Delivery: Engineering the Niche for Regenerative Medicine
This article provides a comprehensive overview of the latest advancements in biomaterial scaffolds for stem cell delivery, a cornerstone of regenerative medicine.
Engineering Cellular Resilience: Innovative Strategies to Overcome Nutritional Stress in Implanted Cells
This article provides a comprehensive analysis of nutritional stress challenges in implanted cells and emerging engineering solutions for biomedical researchers, scientists, and drug development professionals.
Decellularized Extracellular Matrix Scaffolds: Harnessing Native Microenvironments for Advanced Stem Cell Engraftment
This article provides a comprehensive analysis of decellularized extracellular matrix (dECM) as a biological scaffold for stem cell-driven tissue engineering and regenerative medicine.
Oncogenic Potential in Stem Cells: Assessment Strategies and Risk Mitigation for Research and Therapy
This article provides a comprehensive analysis of oncogenic risk assessment across diverse stem cell types, including pluripotent stem cells (PSCs), induced pluripotent stem cells (iPSCs), and adult stem cells.